Psoriasis
Conditions
Interventions
Screening Period:Apply 1% Benvitimod cream topically to the lesions twice daily (morning and evening) for 12 consecutive weeks
Proactive Maintenance Treatment Group:Apply 1% Benvitimod cream twice weekly for 12 weeks
Drug Withdrawal Group:Apply the vehicle cream twice weekly for 12 weeks
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~65 years old; 2. Have typical clinical signs and symptoms, diagnosed with psoriasis (psoriasis with or without palmoplantar area) by 2 or more senior dermatologists for at least 6 months, and involve 10% of the total area =2, the target lesion must be representative of the subject's disease state; 4. Psoriasis patients who are using systemic therapy (including but not limited to cyclosporine, methotrexate, acitretin, apremiste, adalimumab, secukinumab, ixekizumab, guselkumab, upadatinib, etc.) and/or phototherapy have residual skin lesions, and the skin lesions are stable and do not resolve after regular use of systemic therapy and/or phototherapy for nearly 3 months, and systemic therapy and/or phototherapy can continue to be used regularly during the 24-week follow-up period; 5. No external glucocorticoids, calcipotriol, tretinoin and other physical therapy in the past 2 weeks.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women. 2. Patients with severe cardiovascular, pulmonary, renal, or psychiatric diseases. 3. Any other conditions deemed unsuitable for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physician Global Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Psoriasis area and severity index;Body Surface Area; | — |
Countries
China
Contacts
Public ContactWang Wenhui
Peking University Third Hospital
Outcome results
None listed