Unilateral primary aldosteronism
Conditions
Interventions
Adrenal artery embolization intervention group:Adrenal artery embolization
Adrenal artery combined with adrenal vein embolization intervention group:Adrenal artery combined with adrenal vein embolization
Sponsors
The First Affiliated Hospital of Chengdu Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.one Male or female aged 18-75 years; 2. Pre-screening preparation: In hypertensive patients with high suspicion of PA, all antihypertensive therapy should be discontinued for at least 4 weeks prior to screening for PA, and verapamil (180-240 mg/ day), prazosin (6-15 mg/ day), and levamlodipine (2.5-5mg/day) should be sequentialized if office blood pressure exceeds 140/90 mmHg. If participants have hypokalemia, the hypokalemia is corrected by supplementation with oral potassium chloride. Finally, patients with average sitting blood pressure =3.5mmol/L were screened for the presence of PA; 3. After 4 weeks of standard drug elution, Aldosterone-renin-ratio (ARR)>=38 (chemiluminescence method); 4. PA confirmed by saline load or captopril test; 5. Adrenal CT showed unilateral aldosteronoma (tumor diameter =2; 7. Refusal or inadequacy to undergo surgery or medication.
Exclusion criteria
Exclusion criteria: 1.one Other types of secondary hypertension (e.g. renal artery stenosis, hypercortisolism); 2. BPA was confirmed by AVS. 3. CT scan of adrenal gland showed isolated space occupying lesions >2cm in diameter and located on the dominant side of AVS. 4. Severe allergic reaction to contrast media; 5. Renal failure (serum creatinine >176 µmol/L); 6. Women who are pregnant or planning to become pregnant, or who are breastfeeding; 7. Myocardial infarction or cerebral infarction occurred within 3 months and aortic dissection involved the abdominal aorta. 8. Had undergone percutaneous transluminal angiography within the past 3 months; 9. Adrenal artery combined with venous embolization is not suitable for the treatment of adrenal artery with abnormal adrenal vessel anatomy. 10.Had other systemic conditions that could not tolerate the surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Office blood pressure;Ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of antihypertensive drugs;Serum potassium;Plasma renin;Plasma aldosterone; | — |
Countries
China
Contacts
Public ContactWang Peijian
The First Affiliated Hospital of Chengdu Medical College
Outcome results
None listed