Hepatopathy
Conditions
Interventions
Group A:Before the stage of hepatic parenchyma dissection,Normal saline was injected at the rate of 1mL/(kg/h).
Group B:Before the stage of hepatic parenchyma dissection,Normal saline was injected at the rate of 3mL/(kg/h).
Group C:Before the stage of hepatic parenchyma dissection,Normal saline was injected at the rate of 5mL/(kg/h).
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective hepatectomy; 2. Age 18-70 years old; 3. ASA grade ?~?; 4. New York Heart Function Grade I to II; 5. Liver function Child-Pugh A/B grade; 6. There are no other major surgical procedures (spleen, bowel, pancreas surgery).
Exclusion criteria
Exclusion criteria: 1. Obese patients (BMI > 32kg/m²); 2. Patients with severe cardiovascular and cerebrovascular diseases (history of hypertrophic cardiomyopathy, New York heart Function Class III or above, ejection fraction <50%, myocardial infarction, cerebral infarction, and cerebral hemorrhage); 3. Patients with renal insufficiency or renal failure, dyspnea or respiratory failure; 4. Patients with coagulation disorders ( according to the 2024 diagnostic criteria for coagulation disorders) or preoperative anticoagulation therapy; 5. Anemia: patients with total hemoglobin concentration less than 110g/L; 6. Patients with contraindications of arterial and central venipuncture; 7. Refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Operative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood transfusion rate;Grading of surgical field;Arterial blood lactate level; Heart rate;Mean arterial pressure;Stroke Volume;Cardiac Output;Cardiac Output index;Stroke Volume Variation;Systemic Vascular Resistance;Central Venous Pressure;Urine volume;Fluid volume;Dosage of norepinephrine;Nitroglycerin dosage;Number of liquid shocks;The number of hepatic portal blocks;Operation duration;Hepatectomy duration;Albumin;Alanine Aminotransferase;Aspartate Aminotransferase;Creatinine;Total Bilirubin;Direct Bilirubin;Blood Urea Nitrogen;Creatine Kinase Isoenzymes;Myoglobin;High-sensitivity Troponin;N-telencephalic natriuretic peptide precursor;Prothrombin Time;Activated Partial Thromboplastin Time ;Fibrinogen;D-Dimer;Fibrinogen Degradation Products;Extubation Time;ICU Stay;Length of stay;Adverse reaction;Complication;Total hospital expenses;30-day postoperative mortality;Residual alkali in whole blood;pH value;Total hemoglobin concentration; | — |
Countries
China
Contacts
Public ContactOuyang Jie
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed