Allergic Rhinitis
Conditions
Interventions
Group of patients with moderate and severe AR:None
Normal control patient group:None
Mild AR patient group:None
Sponsors
The First Hospital Of Jiaxing
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.AR patients:Between 18 and 65 years of age;Meets the relevant criteria for the diagnosis of allergic rhinitis in the Chinese Guidelines for the Diagnosis and Treatment of Allergic Rhinitis, including nasal, ocular, physical signs, and allergen skin prick test;Patients with persistent exacerbations (symptom onset >= 4 days/week for more than 4 consecutive weeks) who meet the surgical indications for pterygotomy and are first-time patients;Patient hospitals have complete information and signed informed consent forms; 2.The control group:Between the ages of 18 and 65 years old; No history of repeated large amounts of clear watery runny nose, episodic sneezing, nasal itching, etc., and should be negative for the original skin prick test ;Patients with a good mental state, no psychiatric illnesses, and no nasal hypersensitivity; Understanding of the relevant circumstances of this trial, agreeing to participate, and signing an informed consent form.
Exclusion criteria
Exclusion criteria: 1.AR patient exclusion criteria: patients with other allergic diseases; patients who have taken nasal spray hormone, oral glucocorticoid, antihistamine and antibiotic treatment within 2 weeks; patients with neurological diseases or history of diseases, or who have taken drugs related to neurological diseases within 1 month; patients with major medical conditions such as systemic immune diseases or tumors; and other patients who, in the opinion of the investigator, are not suitable to participate in this study; 2.Exclusion criteria for the control group: suffering from allergic diseases and chronic sinusitis and other similar diseases; patients who have taken nasal spray hormones, oral glucocorticosteroids, antihistamines and antibiotic therapy within 2 weeks; suffering from hypertension, diabetes mellitus, malignant tumors and other chronic diseases; suffering from immune-deficiency diseases, such as AIDS; suffering from rheumatoid, systemic lupus erythematosus, and other autoimmune diseases; suffering from psychiatric diseases or mental disorders, or have taken medication related to neurological disorders within 1 month;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNSS score;TRPM3 (mRNA, protein level and immunohistochemistry);VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukins (IL-4, IL-5, IL-13); | — |
Countries
China
Contacts
Public ContactJing Deng
The First Hospital Of Jiaxing
Outcome results
None listed