Post-stroke cognitive impairment
Conditions
Interventions
Dual-target group:Dual-target (right OFC combined with left DLPFC) transcranial magnetic stimulation
control subjects:Single-target (do DLPFC) transcranial magnetic stimulation
Sponsors
Suining Central Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 85 Years
Inclusion criteria
Inclusion criteria: Diagnostic criteria Diagnostic criteria for cerebrovascular disease Refer to the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke (2018) and the Chinese Guidelines for the Diagnosis and Treatment of Cerebral Hemorrhage (2019) published in the Chinese Journal of Neurology for the diagnostic criteria of cerebral hemorrhage or cerebral infarction; imaging evidence of stroke confirmed by computed tomography (CT) scan or magnetic resonance imaging (MRI). Diagnostic criteria of cognitive impairment Refer to the Expert Consensus on the Management of Post-Stroke Cognitive Impairment (PSCIND) issued by the Chinese Stroke Association in 2021: the diagnosis of Post-Stroke Cognitive Impairment Not Dementia (PSCIND) is: (1) cognitive impairment based on baseline; (2) impairment in at least one cognitive domain (executive function, memory, attention, language, visuospatial ability); and (3) the ability of daily life is not greatly affected. Diagnosis of post-stroke dementia (PSD): (1) cognitive decline at baseline; (2) impairment in at least one cognitive domain; (3) severe impairment of daily living ability. 1. Meet the above diagnostic criteria; 2. Age 20-85 years old; 15 days = disease duration = 12 months; stable vital signs, gender is not limited; 3. Clear consciousness, good basic condition, able to cooperate with examination and treatment, with the ability to distinguish between hearing and vision; 4. Evaluate attention, memory, and memory; Cognitive deficits in at least 1 of the domains of attention, memory, language ability, etc. were assessed. The MMSE score is less than 17 in the illiterate group, less than 20 in the elementary school group, and less than 24 in the secondary school or above group. The score of MMSE was less than 17 in the illiterate group, less than 20 in the primary school group, and less than 24 in the secondary school or above group; and the score of MoCA was less than 26. 5. The patients and their families gave informed consent and voluntarily accepted and cooperated with the trial.
Exclusion criteria
Exclusion criteria: 1. Unstable vital signs and progressive stroke; 2. Recurrent stroke; 3. Multiple focal strokes; 4. Presence of a history of epilepsy or factors predisposing to seizures; 5. Family history of depression; 6. Incomplete case information; 7. Cognitive impairment due to other causes (e.g., heavy alcohol consumption, substance abuse, major depressive disorder, Parkinson's disease, brain trauma, etc.) of cognitive impairment; 8. Combination of severe other organ dysfunction or other serious physical diseases; 9. Contraindications to TMS treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA score;MMSE score;MBI score; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6-minute resting quantitative electroencephalogram (QEEG), BDNF, NSE, S100B.;brain-derived neurotrophic factor(BDNF);Neuro-specific enolase;Serum S100B protein; | — |
Countries
China
Contacts
Public ContactKehui Hu
Suining Central Hospital
Outcome results
None listed