Idiopathic short stature
Conditions
Interventions
Control group:Conventional treatment with rhGH combined with vitamin D3 and calcium (specific drug type, dose, and method of use)
Treatment Group:In addition to the control group, 40ug of MK-7 was added
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
4 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1 Those who meet the diagnostic criteria for ISS in the 9th edition of Zhu Futang Practical Pediatrics [height is more than 2 standard deviations lower than the reference value of normal children, growth rate is not less than 5cm/year, bone age is normal or delayed, and growth hormone peak is not less than 10ug/L]; 2 those aged 4-12 years; 3 those who have not used vitamin K or other related drugs in the three months before enrollment; the family members of the children all agree to this study.
Exclusion criteria
Exclusion criteria: 1 Children with pseudo-precocious puberty and partial precocious puberty; 2 Children with congenital malformations and intrauterine growth retardation; 3 Children with organic organ lesions or wasting diseases; 4 Children with malnutrition and skeletal dysplasia; 5 Children with soy allergy; 6 Children who did not receive treatment as required; 7 Children with mental disorders; 8 Children who were lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone age;height; weight;Sexual development stage; | — |
Secondary
| Measure | Time frame |
|---|---|
| bone density ;insulin-like growth factor1;Percent change in absolute serum MK 7 concentration; | — |
Countries
China
Contacts
Public ContactShuang Liang
The Second Hospital of Shandong University
Outcome results
None listed