Symptomatic Atherosclerotic Non-acute Internal Carotid Artery Occlusion
Conditions
Interventions
Observation group:None
Sponsors
The 901st Hospital of Chinese People's Liberation Army Joint Logistic Support Force
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 18 years; 2. Unilateral internal carotid artery occlusion detected by MRA/CTA/DSA; 3. Time from vascular occlusion to treatment exceeds 24 hours (confirmed by imaging or qualifying event); 4. Occurrence of one or more qualifying events related to ipsilateral internal carotid artery occlusion within the past 12 months, including ischemic stroke, TIA, or maurosis fugax (patients with only dizziness or headache are considered asymptomatic); 5. mRS <= 2; 6. The patient and their family are willing to participate in this trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Occlusion caused by non-atherosclerotic diseases such as arterial dissection, Takayasu arteritis, moyamoya disease; vasculopathy induced by herpes simplex virus, varicella-zoster virus, or other viruses; neurosyphilis; leptospiral vasculitis; any type of intracranial infection; radiation-induced vascular occlusion; fibromuscular dysplasia; sickle cell anemia, etc.; 2. History of primary intracranial or intraventricular hemorrhage; 3. Active bleeding within the past 30 days or known bleeding tendency; 4. History of extracranial-intracranial bypass surgery and/or recanalization treatment for the occluded vessel; 5. Patients with severe diseases or functional failure of vital organs such as the heart, liver, kidney, or lungs; patients with tumors; 6. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of a composite of stroke or death within 30 days or ipsilateral ischemic stroke beyond 30 days through 2 years after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of any stroke;The incidence of any death;The incidence of any ischemic stroke;The incidence of any ipsilateral ischemic stroke;Modified Rankin scale;NIHSS scale;MMSE scale;MoCA scale;Symptomatic ICH;The incidence of qualifying vessel restenosis and reocclusion ; | — |
Countries
China
Contacts
Public ContactYu Mingming
The 901st Hospital of Chinese People's Liberation Army Joint Logistic Support Force
Outcome results
None listed