Vascular and neurodegenerative diseases
Conditions
Interventions
The normal control group with true stimulation:tFUS was used to accurately intervene brain regions
Patients with vascular dementia with true stimulation:tFUS was used to accurately intervene brain regions
Patients with Alzheimers disease with true stimulation:tFUS was used to accurately intervene brain regions
The normal control group with sham stimulation:Sham tFUS was used to accurately intervene brain regions
Patients with vascular dementia with sham stimulation:Sham tFUS was used to accurately intervene brain regions
Patients with Alzheimers disease with sham stimulation:Sham tFUS was used to accurately intervene brain regions
Sponsors
Nanjing Drum Tower Hospital of The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Vascular dementia patients: vascular dementia caused by small vessel disease, neuropsychological examination confirmed that the cognitive function is significantly reduced, mainly manifested in memory impairment, orientation, attention, language function, spatial function, executive function, motor control and other functional deficits, with significant decline in social function. The presence of cerebral small vessel disease was examined, and imaging studies proved that the clinical symptoms were due to cerebral small vessel disease. Dementia occurs within 3 to 6 months after cerebrovascular disease. (2) Alzheimer's disease patients: The diagnostic criteria for Alzheimer's disease was the diagnostic criteria proposed by the 2018 Chinese Guidelines for the diagnosis and Treatment of Dementia and cognitive impairment, that is, the cognitive impairment reported by the patient or an informant, or found by an experienced clinician; Objective evidence of impairment in one or more cognitive domains measured on cognitive tests, with cognitive level 1-2 standard deviations below the average of a normal population matched for age, sex, and education. The diagnosis of Alzheimer's disease was confirmed by cerebrospinal fluid, PET-CT, or other relevant evidence. (3) Healthy control group: subjects had no obvious complaints of nervous system related discomfort, such as headache, dizziness, limb weakness and other subjective and objective cognitive dysfunction. For those with junior high school education or above, Mini-mental state examination (MMSE) >= 24 points, Montreal Cognitive Assessment (MoCA) score >= 26; For those with primary school education, MMSE >= 20, MoCA >= 24; Activities of daily living were normal, and the Activity of daily living (ADL) scale was within the normal range matched for age and education.
Exclusion criteria
Exclusion criteria: (1) Patients with hemorrhagic or ischemic acute vascular events in the past three months; (2) patients with mental disorders or drug-induced cognitive impairment. (3) History of severe anxiety, depression, schizophrenia and other mental disorders. (4) cognitive dysfunction caused by central nervous system trauma, alcohol abuse, tumor, metabolic disease, hypothyroidism, infection and other reasons. (5) patients who used antipsychotic drugs or improved cognitive impairment in the past two weeks. (6) There were contraindications such as epilepsy, pacemaker implantation, and cochlear implantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in episodic memory function ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Executive Function;Changes in language function;Changes in Information processing function; | — |
Countries
China
Contacts
Public ContactYun Xu
Nanjing Drum Tower Hospital of The Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed