Strabismus, amblyopia
Conditions
Interventions
Acute Acquired Concomitant Esotropia:None
Healthy control:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
12 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for Amblyopia Patients: age 12-40 years; no gender restriction; diagnoses of strabismic amblyopia, anisometropic amblyopia, refractive amblyopia, and deprivation amblyopia; participants must be able to comply with treatment protocols and attend follow-up visits; participants must be capable of understanding and cooperating with behavioral, EEG, MRI, and eye movement measurements. 2. Inclusion Criteria for Strabismus Patients: age 12-40 years; diagnoses of congenital esotropia, acute functional esotropia, congenital exotropia, and intermittent exotropia; participants must be able to comply with treatment protocols and attend follow-up visits; participants must be capable of understanding and cooperating with behavioral, EEG, MRI, and eye movement measurements. 3.Inclusion Criteria for Normal Controls: age 12-40 years; best corrected visual acuity of 0.9 or better in both eyes; refractive error between -6.00D and +6.00D (inclusive), with astigmatism less than 2.00D; interocular spherical refractive difference less than 1.50D, and interocular cylindrical refractive difference less than 1.00D; regular use of corrective eyewear; normal ocular alignment with horizontal near and distant heterophoria between -10 and +5 PD (inclusive), no vertical heterophoria; normal eye movements; stereopsis (random dot and contour stereotests) <=60"; normal visual function on the synoptophore with simultaneous vision, fusion, and stereopsis present; ability to attend follow-up visits and understand and cooperate with behavioral, EEG, MRI, and eye movement measurements.
Exclusion criteria
Exclusion criteria: 1. Exclusion Criteria for Amblyopia Patients: ocular organic lesions; nystagmus; history of intraocular surgery or refractive surgery; any ocular complications diagnosed within the past 7 months that may impair vision; Down syndrome or cerebral palsy; severe developmental delay as determined by the investigator, such as language or reading disabilities; history of head trauma with associated psychiatric or neurological disorders; metabolic diseases such as diabetes or hyperthyroidism; systemic diseases involving cardiovascular, liver, kidney, or pulmonary organs; history of alcohol or drug abuse; contraindications for MRI, such as claustrophobia; any condition that, in the investigator's judgment, may compromise the safety or well-being of the participant and thus deem them unsuitable for inclusion in the study. 2.Exclusion Criteria for Strabismus Patients: same as the exclusion criteria for amblyopia patients. 3.Exclusion Criteria for Normal Controls: same as the exclusion criteria for amblyopia patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual acuity;Neuroimaging Data;Eye tracking data;Electroencephalogram;Deviation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stereopsis;Adult Strabismus-20;The Amblyopia and Strabismus Questionnaire;National Eye Institute Visual Functioning Questionnaire 25;Self-Rating Depression Scale;Self-Rating Anxiety Scale; | — |
Countries
China
Contacts
Public ContactLiu Longqian
West China Hospital, Sichuan University
Outcome results
None listed