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To explore the efficacy and prognosis of changing GnRHa type or dosage form in estrogen receptor-positive breast cancer patients with ovarian castration escape

To explore the efficacy and prognosis of changing GnRHa type or dosage form in estrogen receptor-positive breast cancer patients with ovarian castration escape

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500098174
Enrollment
Unknown
Registered
2025-03-04
Start date
2024-08-27
Completion date
Unknown
Last updated
2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unilateral primary invasive breast cancer

Interventions

Observation group:None

Sponsors

Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1.A patient with unilateral primary invasive breast cancer diagnosed by histopathology, excluding ocessive breast cancer, inflammatory breast cancer and eczema-like cancer; 2.Operable patients with no distant metastases at diagnosis (stage T1-T3, any N, M0); 3.After diagnosis, the patient was initiated with endocrine therapy and regular GnRHa between January 1, 2013 and December 31, 2023;

Exclusion criteria

Exclusion criteria: 1.Stage IV (metastatic) breast cancer was diagnosed; 2.The patient had undergone bilateral ovariectomy or ovarian radiotherapy before first GnRHa treatment; 3.The patient had not been treated with GnRHa drug castration since diagnosis; 4.The patient was postmenopausal at first diagnosis (no menstruation in the past 12 months or menopausal hormone levels at diagnosis, E2 30U/L); 5.The investigator determined that the patient had any other condition that made her unfit to participate in the study;

Design outcomes

Primary

MeasureTime frame
Estradiol;

Secondary

MeasureTime frame
Follicle Stimulating Hormone;Luteinizing Hormone;Anti-Mullerian Hormone;Menstruation;

Countries

China

Contacts

Public ContactQiang Liu

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

Victorlq@hotmail.com+86 20 81332587

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026