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Effects of flurbiprofen axetil combined with nerve block multi-mode total analgesia on postoperative pain, sleep and short-term cognition in elderly patients with hip fracture

Effects of flurbiprofen axetil combined with nerve block multi-mode total analgesia on postoperative pain, sleep and short-term cognition in elderly patients with hip fracture

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500098159
Enrollment
Unknown
Registered
2025-03-04
Start date
2023-10-30
Completion date
Unknown
Last updated
2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Femoral neck fracture, intertrochanteric fracture

Interventions

Experimental group:Ultrasound-guided fascia iliaca compartment block combined with intravenous infusion of flurbiprofen axetil
Control group:Intravenous infusion of flurbiprofen axetil

Sponsors

The First Affiliated Hospital of Nanchang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age > 65 years old, gender unlimited 2. The diagnosis of unilateral femoral neck fracture or intertrochanteric fracture meets the indications for surgical treatment, and half-hip or total hip replacement is proposed 3. ASA grade is II ~ III 4. BMI 18 ~ 28kg/m^2 5. Visual analog scoring method score >=5 points

Exclusion criteria

Exclusion criteria: 1. A history of neurological or psychiatric disorders 2. History of chronic pain 3. Have a history of alcoholism or long-term use of psychotropic drugs 4. Severe visual or hearing disorders 5. Patients with cognitive dysfunction proved by the MMSE before surgery (illiteracy score <17, primary school education score <20, junior high school education score <24) 6. Patients who cannot cooperate to complete the relevant questionnaire survey 7. Past allergy to narcotic drugs 8. The puncture site has inflammation, infection and other puncture contraindications 9. Patients with digestive tract ulcer

Design outcomes

Primary

MeasureTime frame
Sleep situation;Pain situation;Analgesics usage;Cognitive situation;Substance P;Inflammatory factors;

Secondary

MeasureTime frame
adverse reactions;

Countries

China

Contacts

Public ContactFusheng Wei

The First Affiliated Hospital of Nanchang University

Fusheng5133@163.com+86 137 5564 5791

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026