Postoperative Cognitive function
Conditions
Interventions
Dexmedetomidine low-dose group:At the time of induction of anesthesia, 0.4ug/kg/h dexmedetomidine was given intravenously and stopped 30 minutes before the end of surgery.
Dexmedetomidine high-dose group:At induction of anesthesia 0.8ug/kg/h dexmedetomidine was given intravenously and discontinued 30 minutes before the end of surgery.
Normal saline group:Intravenous infusion of an equal volume of normal saline
Sponsors
Shengjing Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 30 and 65 years old; 2. ASA I-III; 3. BMI between 18 and 30 kg/m²; 4. Planning gynecological laparoscopic surgery under general anesthesia, expected pneumoperitoneum time of 1 to 3 hours; 5. Communication was smooth, and informed consent was obtained from the patient and his family members.
Exclusion criteria
Exclusion criteria: 1. Patients with a previous history of neurological, psychiatric or traumatic brain injury diseases; Patients with drug or alcohol addiction; 2. Special users who cannot tolerate narcotic drugs; 3. Education is Illiteracy; 4. Patients with visual, hearing and presentation disorders that may affect the assessment of memory function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameter;Mini-mental State Examination;Montreal Cognitive Assessment;Regional Cerebral Oxygen Saturation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure, diastolic blood pressure, mean arterial pressure;Heart rate;Length of stay; | — |
Countries
China
Contacts
Public ContactDongyi Tong
Shengjing Hospital of China Medical University
Outcome results
None listed