Patients requiring thyroidectomy surgery due to thyroid disease
Conditions
Interventions
Control group (5ml physiological saline):Esketamine
S1 group (0.2mg/kg esketamine group):0.2mg/kg esketamine group
S2 group (0.25mg/kg esketamine group):0.25mg/kg esketamine group
S3 group (0.3mg/kg esketamine group):0.3mg/kg esketamine
Sponsors
Ningbo Medical Centre Lihuili Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 120 patients underwent thyroidectomy under general anesthesia between February 2025 and December 2025;
Exclusion criteria
Exclusion criteria: 1.The patient has severe obstructive ventilation dysfunction, bronchial asthma, and upper respiratory infection; 2.Preoperative electrocardiogram indicates rapid arrhythmia; 3.Severe pulmonary arterial hypertension; 4.Cardiac function level III-IV; 5.Mental illness; 6.Uncontrolled severe hypertension before surgery; 7.Hyperthyroidism; 8.Severe liver and kidney dysfunction; 9.Difficult airway; 10.History of allergy to anesthetic drugs in the study; 11.Increased intracranial pressure or intraocular pressure; 12.Patients who have recently taken sedatives and analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of coughing reaction and changes in blood volume in the drainage bottle during the patient's awakening period; | — |
Countries
China
Contacts
Public Contactfei zhang
Ningbo Medical Centre Lihuili Hospital
Outcome results
None listed