Bronchopulmonary dysplasia
Conditions
Interventions
Low-dose group:received an infusion of ACB-MNCs with 24 h after birth,cell dose was targeted at 1-4.99 ×10^7 cells per kilogram
High-dose group:received an infusion of ACB-MNCs with 24 h after birth,cell dose was targeted at 10 ×10^7 cells per kilogram
placebo-controlled group:received 4 ml normal saline with 24 h after birth.
Sponsors
The first affiliated hospital of USTC
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Born at study hospital 2.Gestational age (GA) <32 weeks 3.singleton birth 4.Informed consent form signed by the legal representative
Exclusion criteria
Exclusion criteria: 1.Serious congenital abnormalities (chromosomal abnormalities, severe congenital malformations) 2.Mother has sepsis or severe infectious disease 3.Surgery is required within 48 hours before or after ACB-MNCs infusion 4.Those who fail the umbilical cord blood collection and testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of BPD;The severity of BPD;The level of KL-6 in peripheral blood;The level of ANG-1 in peripheral blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of other complications in premature infants;The respiratory support duration;The usage time of antibiotics; | — |
Countries
China
Contacts
Public ContactMingwu Chen
The first affiliated hospital of USTC
Outcome results
None listed