Chronic nasosinusitis
Conditions
Interventions
Chronic sinusitis group:None
Control group:None
Sponsors
The First Affiliated Hospital of PLA Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (1) The subject must sign the informed consent voluntarily (2) Age >=18 years old and <=55 years old. (3) Chronic sinusitis group: 1. The diagnosis of the subjects met the diagnostic criteria of chronic sinusitis with nasal polyps in the whole group of "Chinese Guidelines for the Diagnosis and Treatment of Chronic Sinusitis (2018)"; 2. The subjects met the "Chinese Guidelines for the Diagnosis and Treatment of Chronic Sinusitis (2018)". 3. No previous history of nasal surgery; 4. Grouping of olfactory scores: Anosmia group: CRSwNP patients with <15 points scored by Sniffin 'Sticks olfactory test (TDI) before surgery. Patients with decreased sense of smell: CRSwNP patients with 15 points <= 30 points were scored by Sniffin 'Sticks smell test (TDI) before surgery. Group with normal sense of smell: CRSwNP patients with 30 points or less scored by Sniffin 'Sticks smell test (TDI) before surgery. (4) Control group: 1. Patients undergoing skull base surgery or nasal endoscopic surgery due to anatomical abnormalities 2. No previous history of nasal and sinus tumors or inflammation 3. Score by Sniffin 'Sticks Smell Test (TDI), 30 points < score
Exclusion criteria
Exclusion criteria: Exclusion criteria (1) Those who voluntarily asked for withdrawal had poor compliance and could not cooperate with regular follow-up and treatment observers (2) Subjects have the following conditions: asthma, eosinophilia, phantom or olfactory hypersensitivity, cystic fibrosis, congenital ciliary dyskinesia, nasal tumors, naso-facial malformations, history of naso-facial trauma resulting in nasal obstruction, invasive or non-invasive fungal sinusitis, and anaphylactic sinus abnormalities. (3) a serious metabolic, cardiovascular, immune, neurological, blood, digestive, cerebrovascular, or respiratory disease, or a disease that the investigator has assessed could affect the study results or the safety of the subjects. (4) Serious systemic complications occurred during and after the operation, including orbital and intracranial complications (5) Staff members who are currently participating in another clinical study or who have participated in another clinical investigator within 30 days, or who are directly involved in this study. (6) A history of mental illness, antagonistic personality, bad motivation, paranoia, or other emotional or intellectual problems that may affect the informed effectiveness of participants in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sniffin 'Sticks Smell Test (TDI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient quality of life score (SNOT-22 table, namely 22 tables of nasal and sinusoidal outcome measurement);Olfactory symptom scale (VAS, Visual Analogue scale);Lund-Mackey Rating;Lund-Kennedy Rating;Nasal ventilation function test; | — |
Countries
China
Contacts
Public ContactChen Fuquan
The First Affiliated Hospital of PLA Air Force Medical University
Outcome results
None listed