Patients with early or mid-stage ACLF/SACLF due to hepatitis B were diagnosed and screened according to the standards set in the "Guidelines for the Diagnosis and Treatment of Liver Failure (2018 Edition)" and also met the indications outlined in the "Expert Consensus on Clinical Application of Artificial Liver Blood Purification Technology (2022 Edition)."
Conditions
Interventions
DPMAS+PE group:The dual plasma molecular adsorption system combined with plasma exchange
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients with early or mid-stage ACLF/SACLF due to hepatitis B were diagnosed and screened according to the standards set in the "Guidelines for the Diagnosis and Treatment of Liver Failure (2018 Edition)" and also met the indications outlined in the "Expert Consensus on Clinical Application of Artificial Liver Blood Purification Technology (2022 Edition).";
Exclusion criteria
Exclusion criteria: Anyone who meets one of the following criteria is eliminated, including those younger than 18 years or older than 70 years of age, advanced ACLF/SACLF (i.e., PTA = 2.6, or with >= 2 complications/extrahepatic organ failure), overlapping other hepatitis virus infections (such as HCV, HIV, etc.), liver failure caused by other causes (such as alcoholic liver disease, autoimmune liver disease, etc.), and relative contraindications in the Expert Consensus on the Clinical Application of Artificial Liver Blood Purification Technology (2022 Edition) (i.e., active bleeding/DIC, severe allergies such as plasma/heparin/protamine, hemodynamic instability, unstable infarction caused by cardiovascular and cerebrovascular accidents, extravascular hemolysis, severe sepsis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMSC differentiation factors include HGF, FGF-4, EGF, and bFGF.; | — |
Countries
China
Contacts
Public ContactFan Yang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed