mild cognitive impairment
Conditions
Interventions
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. age: 50-85 years old; 2. patients with a diagnosis of mild cognitive impairment (MCI) or early-stage dementia (according to international classification criteria, e.g., DSM-5 or NIA-AA); MMSE >= 20 points, or Clinical Dementia Rating , CDR <= 1. 3. signed informed consent;
Exclusion criteria
Exclusion criteria: 1. Comorbidity with severe other neurological diseases (e.g. Parkinson's disease, stroke, etc.); 2. Suffering from severe depression, mental illness or unable to cooperate with the assessment; 3. Comorbidity with major physical diseases (e.g. cardiac and renal failure). 4. those who refuse to undergo blood sampling, imaging, etc. 5. those who are contraindicated for MRI examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Basic; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE;Blood Marker Aß1-40 Screening;tau-PET braak staging;Blood Marker Aß1-42 Screening;Cerebrospinal fluid marker p-tau217 assay;CDR Score; | — |
Countries
China
Contacts
Public ContactJiawei Xin
Fujian Medical University Union Hospital
Outcome results
None listed