Ischemic Stroke
Conditions
Interventions
Sponsors
Second Affiliated Hospital of Army Medical University, PLA
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >=18 years; 2) Within 24 hours of stroke onset; 3) Anterior circulation intracranial large vessel occlusive stroke confirmed by CTA/MRA/DSA; 4) NIHSS score >5 points; 5) The admission blood routine test revealed white blood cells >10×10^9/L and lymphocytes <0.8×10^9/L. 6) Received endovascular therapy; 7) Patients or their family members provided written informed consent.
Exclusion criteria
Exclusion criteria: 1) Suspected or confirmed intracranial hemorrhage by head CT or MRI; 2) Pre-stroke mRS score >= 2; 3) Pregnant or lactating women; 4) Allergy to contrast agent; 5) Allergy to glucocorticoid; 6) Currently participating in other clinical trial; 7) Systolic blood pressure greater than 180 mmHg or diastolic blood pressure greater than 110 mmHg after aggressive treatment; 8) Genetic or acquired bleeding tendency, deficiency of coagulation factors; or use of anticoagulants with INR>1.7; 9) Serum glucose lower than 2.8mmol/L (50mg/dl) or greater than 22.2mmol/L (400mg/dl); 10) Arterial tortuosity preventing thrombectomy device access to target vessel; 11) Serious systemic hemorrhage in the past 30 days; 12) Chronic hemodialysis and severe renal insufficiency patients (glomerular filtration rate220µmol/L; 13) Any disease that leads to an expected lifespan of less than 6 months; 14) Unable to complete follow-up as expected; 15) Previous intracranial aneurysm, arteriovenous malformation; 16) Previous mass lesions; 17) Macular edema; 18) History of Mohs type II second/third degree atrioventricular block or sick sinus syndrome; 19)Systemic infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of 90-day mRS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of 90-day mRS Scores 0-1;The proportion of 90-day mRS Scores 0-2;The proportion of 90-day mRS Scores 0-3;The proportion of 90-day mRS Scores 0-4;Changes of NIHSS score 5-7 days after surgery;90-day EQ-5D scale score;90-day mortality;Incidence of symptomatic intracranial hemorrhage;Incidence of any intracranial hemorrhage within 48 hours;Incidence of malignant cerebral edema within 48h after surgery; | — |
Countries
China
Contacts
Public ContactQingwu Yang
Second Affiliated Hospital of Army Medical University, PLA
Outcome results
None listed