Mànxìng jingshén fenliè zhèng 7 / 5,000 Chronic schizophrenia
Conditions
Interventions
Observation Group:Hyperbaric oxygen therapy was added to the control group. The patients entered a large multi-person air pressurized oxygen chamber, with pure oxygen masks, the cabin pressure was set
Sponsors
Chaohu Hospital Affiliated to Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. After a structured clinical interview by two or more attending psychiatrists, the patient meets the diagnostic criteria of DSM-5 or ICD-11 for schizophrenia; 2. The duration of illness is = 2 years, which meets the definition of chronic schizophrenia; 3. The age range is 18-60 years old; 4. There is no obvious acute mental symptom in the past 3 months, and the condition is stable and can cooperate with the research requirements; 5. The patient is receiving a stable dose of antipsychotic drugs for at least 1 month, and there is no plan to adjust the dose; 6. The patient and the guardian can understand the content of the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe physical illness: such as severe cardiovascular and cerebrovascular diseases, lung diseases (such as pneumothorax, chronic obstructive pulmonary disease), etc., who cannot tolerate hyperbaric oxygen therapy; 2. Other mental disorders: such as comorbidities such as bipolar disorder, major depression or neurodevelopmental disorders; 3. Drug dependence: alcohol or substance use disorder (excluding nicotine) currently or in the past year; 4. Pregnancy or lactation: female patients are pregnant or lactating; 5. History of epilepsy: past or current history of epileptic seizures; 6. Contraindications to hyperbaric oxygen: including uncontrolled hypertension, otitis media, severe autism, etc.; 7. Others: any condition that may affect study compliance or data accuracy (such as intellectual disability, severe language communication barriers).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale (PANSS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Personal and Social Performance Scale; | — |
Countries
China
Contacts
Public ContactZhang Kai
Chaohu Hospital Affiliated to Anhui Medical University
Outcome results
None listed