Depression
Conditions
Interventions
Experimental group:Active rTMS + Active CCT
Control group:Active rTMS + Sham CCT
Sponsors
The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: Ethnic Chinese; aged 55 to 75 years; right-handed; living at home; having a primary diagnosis of major depressive disorder (single or recurrent episodes without psychotic features) based on DSM-5 criteria; current episode scoring >17 in the Hong Kong Chinese version of the 17-item Hamilton Rating Scale for Depression (HAM-D), with cognitive symptoms [Item 8 in HAM-D (slowness of thought and speech, impaired ability to concentrate) scoring =2]; not responding to an adequate dose of an antidepressant; and having received a stable antidepressant regimen for at least 4 weeks before joining this trial.
Exclusion criteria
Exclusion criteria: Alcohol or substance abuse; bipolar disorder; any psychotic disorder or current psychotic symptoms; dementia; active suicidal ideation; anxiety disorder; personality disorder; mental disorder due to organic cause; neurological disorders (Parkinson’s disease, stroke, brain tumor); and unstable physical illness. Individuals identified with these conditions will be excluded and referred to the Hospital Authority for further management. Other exclusion criteria are: history of seizure or epilepsy; contraindications to magnetic resonance imaging (MRI); metallic implants in cephalic region (including aneurysm clips, shuts, stimulators, cochlear implant, or electrodes); history of receiving non-invasive brain stimulation (TMS, tDCS, tACS, etc.), electroconvulsive therapy, cognitive training, or psychological intervention in the past 6 months; refusing blood taking or MRI; or having language barrier or communication impairments (poor vision and hearing despite correction).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAM-D score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mood;Cognition;Level of functioning;Functional brain network;Cortical excitability;Serum BDNF level; | — |
Countries
China
Contacts
Public ContactAllen Ting Chun Lee
The Chinese University of Hong Kong
Outcome results
None listed