Postoperative delirium
Conditions
Interventions
Experimental group:Before the operation, we placed a high-frequency (5-10 MHz) ultrasound probe in the anterior cervical area on the right side. The ultrasound probe (S-Nerve, SonoSite Inc. ), using i
Control group:Before the operation, we placed a high-frequency (5-10 MHz) ultrasound probe in the anterior cervical area on the right side. The ultrasound probe (S-Nerve, SonoSite Inc. ), using in-pla
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Obtain informed consent; 2. Age>=60 years, <=90 years; 3. Patients who intend to undergo hip surgery under general anesthesia; 4. American Society of Anesthesiologists (ASA) grade II~III
Exclusion criteria
Exclusion criteria: 1. Severe heart, lung, liver and kidney dysfunction; 2. History of psychiatric illness or long-term psychotropic drugs (dementia, schizophrenia), chronic analgesic drugs, and alcoholism; 3. Patients with positive preoperative CAM 4. Patients with severe cognitive impairment diagnosed with preoperative Brief Mental State Questionnaire (SPMSQ) >=8 errors; 5. Any cerebrovascular accident within 3 months, such as stroke, transient ischemic attack (TIA), etc.; 6. Diabetic patients with severe diabetic complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macrovascular disease, diabetic nephropathy); 7. Patients with severe infections; 8. Preoperative PaO2<60mmHg or SpO2<92%; 9. Participated in other drug clinical studies within the past 30 days; 10. Verbal communication disorder, unable to complete cognitive function tests; 11. Patients with prosthetic fracture revision; Patients with hip fractures with severe trauma to other sites; 12. Those who are allergic to the test drug or have other contraindications to fascia iliaca
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of postoperative delirium within 3 days after surgery;Subtypes of delirium 3 days after surgery;The degree of pain during rest and activity;Postoperative sleep quality score;Postoperative anxiety score;Postoperative depression score;Dosage of analgesic drugs after surgery;The number of hypotension, bradycardia, hypertension, and tachycardia that require drug intervention during surgery;Post-operative hospitalization;Postoperative complications other than delirium;Incidence of nausea and vomiting;Whether to be transferred to the ICU and the number of days to stay after the operation;All-cause mortality rate 30 days after surgery;Dextrometomidine blood concentration;Serum lactic acid value;Calcitonin gene-related peptide;Norepinephrine;Heart rate variability and related indicators;Analysis of patient EEG monitored by Patient status index (PSI) (including the proportion of various waveforms, etc.); | — |
Countries
China
Contacts
Public ContactCheng Xinqi
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed