Parkinson's disease
Conditions
Interventions
Esmolamine group (group ES).:In ES group, 0.25mg/ Ketamine was given at the time of anesthesia induction and 0.125mg/ (kg ·h) was pumped to 30 minutes before the end of operation.
Control group (group C):Group C was injected with saline at the same time.
Sponsors
Yancheng Third People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age 60-90; 2. Regardless of gender; 3. American Association of Anesthesiologists (American Society of Anesthesiologists,ASA) rating: grade I ~ III; 4. Diagnosis of Parkinson's disease; 5. Non-craniocerebral surgery under general anesthesia; 6. Volunteer to participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. With severe depression or other mental illness, it is impossible to accurately assess the state of depression (oral antidepressants); 2. Severe heart, liver or kidney disease before operation; 3. Body mass index (BMI) > 35 kg/m^2; 4. Those who have communication difficulties or are unable to cooperate; 5. Uncontrolled hypertension (baseline value-gt;180/100mmHg); 6. Allergic or taboo use of esmolamine (history of glaucoma or hyperthyroidism).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-Rating Depression Scale(SDS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-HT;NA;TNF-a;IL-6; | — |
Countries
China
Contacts
Public ContactWang Shu
Yancheng Third People's Hospital
Outcome results
None listed