Lnguinal hernia
Conditions
Interventions
Opioid-free general anesthesia group (OFA group):Opioid-free general anesthesia
Opioid anesthesia group (OA group):Opioid anesthesia
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 18 < age < 70 years; ASA Grading I.~III; Gender is not limited; 18<BMI<30kg/m^2;Able to understand and comply with the study protocol, able to communicate, and agree to sign informed consent
Exclusion criteria
Exclusion criteria: Incarcerated hernia; pregnant women; expected operation duration > 1h; severe heart disease (NYHA cardiac function grade > 3), severe renal insufficiency (serum creatinine > 1.8mg/dL (159.1µmol/L) or receiving renal replacement therapy), severe liver insufficiency (modified Child - Pugh grade C); severe arrhythmia, bradycardia, sick sinus syndrome, heart block; severe coagulation disorder (PT prolongation = 6s or INR > 1.4), abnormal platelet count (platelet count > 50 × 10^9/L); allergic to study drugs; history of drug abuse such as opioids; other contraindications for anesthesia or surgery; refusal to sign the informed consent form; participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of acute postoperative pain (the area under the AUC curve drawn by the VAS score recorded from T5 to T9).; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score when getting out of bed and moving around at 6 hours after surgery (T7*).;The number of times ketorolac tromethamine is required for remedial analgesia within 24 hours after surgery.;PCIA utilization rate;Incidence of adverse events;Quality of recovery score (QoR - 15);Daytime ward discharge failure rate;The incidence of CPIP at 3 months after surgery.;Intraoperative hemodynamic parameters (MAP; HR).; | — |
Countries
China
Contacts
Public ContactBo Lulong
Shanghai Changhai Hospital
Outcome results
None listed