Clinical study on probiotics assisted treatment of knee osteoarthritis in postmenopausal women

Clinical study on Probio-M8 assisted treatment of osteoporosis combined with knee osteoarthritis in postmenopausal women

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500098046

Enrollment

Unknown

Registered

2025-02-28

Start date

2021-06-14

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

Probiotics-assisted therapy group:Chondroitin sulfatet + Probiotics

Placebo-controlled group:Chondroitin sulfate + Placebo

Eligibility

Sex/Gender

Female

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Postmenopausal women aged 50 to 70 years; 2. Clinical diagnosis of knee osteoarthritis; 3. Written informed consent for participation in the study.

Exclusion criteria

Exclusion criteria: 1. Use of probiotics or prebiotics within the last 2 weeks; 2. Known allergy to lactic acid bacteria or their products; 3. Presence of cardiovascular diseases, renal insufficiency, malignant tumors, infectious diseases, or digestive tract diseases; 4. History of abdominal surgery; 5. Requirement for antibiotic treatment during the study period; 6. Mental conditions compromising the ability to provide informed consent.

Design outcomes

Primary

Measure	Time frame
Western Ontario and McMaster Universities Arthritis Index;	—

Secondary

Measure	Time frame
Interleukin-2;Interleukin-4;Interleukin-6;Interleukin-10;Interleukin-17A;Tumor necrosis factor-a;Interferon-?;	—

Countries

China

Contacts

Public ContactJianmin Zhao

Affiliated Hospital of Inner Mongolia Medical University

nmzjmin@163.com+86 136 0471 9169

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026