Colorectal cancer
Conditions
Interventions
Observation Group:None
Control group:None
Sponsors
Yantai Affiliated Hospital of Binzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >=18 years, confirmed diagnosis of colorectal adenocarcinoma (based on postoperative pathology or biopsy pathology), clinical stage I-IV; 2) Prospective study (2025.01-2027.12) requires signed informed consent and voluntary provision of tumor tissue, paracancerous tissue and peripheral blood samples; 3) Retrospective cohort (2019.01-2023.12) requires complete clinical data and follow-up records (including date of diagnosis, treatment regimen, survival status, etc.); 4) Have not received radiotherapy or targeted therapy (preoperative neoadjuvant therapy patients can be included); 5) Can cooperate to complete long-term follow-up (for retrospective analysis).
Exclusion criteria
Exclusion criteria: 1) comorbidity with other malignant tumors or systemic immune disorders; 2) Presence of severe hepatic or renal insufficiency, cardiovascular or cerebrovascular disease or other comorbidities that may affect the survival analysis; 3) Missing clinical information or incomplete follow-up data (e.g., missed visits, incorrect contact information, etc.); 4) Pathological type of non-adenocarcinoma (e.g. neuroendocrine tumor, lymphoma, etc.); 5) hemolysis or substandard tissue preservation during sample collection (for prospective studies only).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expression level of SPHK1;The expression level of hsa_circ_0001642;The expression level of hsa-miR-193a-5p;Survival outcome indicators;Diagnostic effectiveness indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of clinicopathologic parameters;Patient quality of life scores; | — |
Countries
China
Contacts
Public ContactYandong Miao
Yantai Affiliated Hospital of Binzhou Medical University
Outcome results
None listed