Knee osteoarthritis
Conditions
Interventions
Experimental Group:Basic therapy and PRP from young donors
Control Group:Basic therapy and autologous PRP from elderly patients
Sponsors
The General Hospital of Western Theater Command, Chengdu 610083, China
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of knee osteoarthritis: The diagnostic criteria for knee osteoarthritis (KOA) are: meeting the condition of "repeated knee pain within the last month" and fulfilling any two of the following items: 1 patient age >= 50 years old; 2 morning stiffness lasting no more than 30 minutes; 3 crepitus (sensation) during joint movement; 4 X-ray imaging in the upright or weight-bearing position showing subchondral bone sclerosis, joint space narrowing, and/or osteophyte formation and cystic changes at the joint margin. 2. Age over 60 years old; 3. Patients with positive clinical manifestations of KOA and X-ray Kellgren & Lawrence grade I to III (mild to moderate) confirmed as early to mid-stage knee osteoarthritis; 4. Never received intra-articular injection treatment for the knee joint before; 5. No diseases affecting platelet quantity and function, such as thrombocytopenia or platelet dysfunction; 6. Not taking antiplatelet drugs such as aspirin; 7. Good overall health, without life-threatening major diseases; 8. The subjects have the ability to make independent judgments and express themselves verbally, and have good compliance; 9. The subjects themselves must be informed and consent to voluntarily accept and cooperate with the treatment plan of this trial.
Exclusion criteria
Exclusion criteria: 1. Those who do not meet the inclusion criteria; 2. Prior treatment with PRP or other cartilage repair therapy; 3. There are other diseases affecting the knee joint, such as rheumatoid arthritis, osteomyelitis, gout, etc. 4. Severe dysfunction of the heart, liver, kidney and other organs; 5. Patients with mental illness or cognitive or speech disorders; 6. There is systemic inflammatory disease, and glucocorticoids have been injected in the past 3 months; 7. The number of platelets is too small or dysfunctional, there is a clotting disorder or anticoagulation therapy is being carried out; 8. Presence of blood-borne diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| X-ray of the knee joint;Knee MRI;WOMAC Index;Hospital for Special Surgery Knee Score;Visual Analogue Scale for Pain;36-item Short Form HealthSurvey;Serological Testing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine test;Blood Typing and Crossmatching;Infectious Disease Panel of Nine Tests;Platelet Count;Anti-HLA Antibody Detection;CD62P;Growth Factor Expression Detection; | — |
Countries
China
Contacts
Public ContactRizhao Pang
The General Hospital of Western Theater Command, Chengdu 610083, China
Outcome results
None listed