Effect of esketamine on the incidence of postoperative delirium in elderly trauma patients:A prospective, randomized, double-blind, controlled study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500098010

Enrollment

Unknown

Registered

2025-02-28

Start date

2024-04-10

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

elderly Trauma

Interventions

esmketamine group:Intraoperative continuous pumping of 0.25 mg/kg/h until 10 minutes before the end of surgery

dexmedetomidine group:Intraoperative continuous pumping of 0.125 mg/kg/h until 10 minutes before the end of surgery

Eligibility

Sex/Gender

All

Age

65 Years to 95 Years

Inclusion criteria

Inclusion criteria: 1.Elderly patients =65 years of age, regardless of gender 2.ASA physical condition class I-III 3.capable of autonomous behavior, conscious, and able to cooperate in the completion of the study 4.Undergoing surgical procedures under general anesthesia

Exclusion criteria

Exclusion criteria: 1. patient refusal to participate in the study; 2. severe visual or auditory deficits; cognitive impairment or inability to communicate; 3. positive preoperative delirium assessment method (CAM); 4. body mass index BMI greater than 30; 5. glaucoma or intracranial hypertension; severe uncontrolled hypertension; and 6. allergy to esketamine and dexmedetomidine.

Design outcomes

Primary

Measure	Time frame
Postoperative Delirium;	—

Secondary

Measure	Time frame
Propofol usage;Remifentanil dosage;Incidence of postoperative adverse events;	—

Countries

China

Contacts

Public ContactRu Jin

Xuzhou Renci Hospital

19775453@qq.com+86 159 5226 5921

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026