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Effect of goal-directed fluid therapy on the quality of endocalyx and near-term recovery in elderly patients undergoing laparoscopy: a double-blind, randomized, controlled clinical study

Effect of goal-directed fluid therapy on the quality of endocalyx and near-term recovery in elderly patients undergoing laparoscopy: a double-blind, randomized, controlled clinical study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097999
Enrollment
Unknown
Registered
2025-02-28
Start date
2025-03-05
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hernia/gallstones

Interventions

The control group:Restricted fluid therapy

Sponsors

Nanchong Central Hospital of Sichuan Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
75 Years to 90 Years

Inclusion criteria

Inclusion criteria: (1) Age >=75 years old; (2) ASA Grade II ~ III; (3) "laparoscopic cholecystectomy/hernia repair" is planned to be performed at an selected time; (4) Voluntarily participate in this study and sign a written informed consent for anesthesia.

Exclusion criteria

Exclusion criteria: (1) Combination of poorly controlled diabetes and impaired glucose tolerance; (2) Weight loss of more than 10% in the past 6 months; (3) Patients with nausea, vomiting, gastroesophageal reflux, gastric emptying disorder, pyloric obstruction, etc.; (4) Complicated with severe brain, heart, lung, liver and kidney diseases. (5) Suspected or have a history of alcohol or drug abuse; (6) Patients with a history of Alzheimer's disease, Parkinson's disease, delirium; (7) There are serious sensory defects (such as vision, hearing impairment) or other reasons caused by the inability to communicate with the visitor and affect the evaluator.

Design outcomes

Primary

MeasureTime frame
Syndecan-1;TNF-a;IL-1;ICAM-1;VCAM-1;

Secondary

MeasureTime frame
mean arterial pressure;heart rate;rSO2;

Countries

China

Contacts

Public ContactWuchang Fu

Nanchong Central Hospital of Sichuan Province

14834043@qq.com+86 139 9082 0494

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026