Patients who are scheduled to undergo open reduction and internal fixation for ankle fractures
Conditions
Interventions
The low-background group:PCIA with a low background dose
The high-background group:PCIA with a high background dose
The delayed-high-background group:PCIA with a high background dose given from postoperative hour 6
Sponsors
Zhongda hospital southeast university
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.The participants' age range was from 20 to 60 years. 2.An elective procedure of open reduction and internal fixation was conducted for the ankle fracture. 3.American Society of Anesthesiologists (ASA)status were grade I - II.
Exclusion criteria
Exclusion criteria: 1. Coagulation dysfunction; 2. Neuropathy; 3. Local anesthetic allergy; 4. Serious heart and lung disease; 5. Systemic steroid use; 6. Before operation, the liver and kidney are not in the normal range, complicated with severe respiratory dysfunction (type I or type II respiratory failure); 7. Pregnancy; 8. Severe obesity (BMI 35kg/m2); 9. A history of drug and alcohol abuse (alcoholism is defined as drinking more than 14 units of alcohol per week - 1 unit of alcohol =360 mL beer or 45 ml spirits with 40% alcohol or 150 mL wine); 10. Previous long-term use of opioid or non-opioid analgesics; Preexisting underlying pain (chronic pain).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of rebound pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;Consumption of opioids;Plasma cortisol;The incidence of postoperative nausea and vomiting (PONV);Sleep quality; | — |
Countries
China
Contacts
Public ContactJue Xie
Zhongda hospital southeast university
Outcome results
None listed