Sepsis shock
Conditions
Interventions
Cyclopofol group:A loading dose of 0.1 mg/kg of intravenous propofol was given intravenously over 4 minutes +/-30 s, followed immediately by an initial dose of 0.3 mg/kg/hour, and the dosing rate was
Propofol group:A loading dose of 0.5 mg/kg of propofol was given as an intravenous infusion over 4 minutes +/-30 s, followed immediately by an initial dose of 1.5 mg/kg/hour, and the dosing rate was a
Sponsors
Department of Intensive Care Medicine, Ningbo Medical Center LiHuiLi Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years; 2. Patients with septic shock who require invasive mechanical ventilation; 3. Expected need for long-term sedation (>=24 hours); 4. The target Richmond agitation-sedation scale (RASS) of the patient's required sedation is +1 to -2 points; 5. Patients or their family members sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known or suspected allergy to cyclopofol or propofol and their antidotes; 2. The patient has been sedated in the ICU or general ward for more than 3 days before signing the informed consent form; 3. Pregnant or lactating; 4. Other conditions judged by the investigator that the patient is not suitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Norepinephrine requirements in the first 24h after randomization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Norepinephrine requirements in the 0, 12, 48, 72, 96h after randomization;Cumulative dose of norepinephrine;Duration of use of norepinephrine;Success rate of sedation;Duration of invasive mechanical ventilation;Hospital mortality;Length of ICU stay;Total length of stay;Total hospital costs; | — |
Countries
China
Contacts
Public ContactDong Zhouzhou
Ningbo Medical Center LiHuiLi Hospital
Outcome results
None listed