Mild cognitive impairment
Conditions
Interventions
Bifidobacterium breve CCFM1179 group:Bifidobacterium breve CCFM1179
placebo group:placebo
health group:None
Sponsors
Yixing People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Age 60-89 years, no restriction on gender; 2. Meets MCI clinical criteria (DSM-5); 3. Written informed consent provided for participation in the study;
Exclusion criteria
Exclusion criteria: 1. Subsequent complications caused by Parkinson's disease, Huntington's disease, normal pressure hydrocephalus, progressive supranuclear palsy, epilepsy, multiple sclerosis, brain infection or head trauma; A history of major depression or bipolar disorder, alcohol or other substance abuse; The discovery of multiple infarcts, brain tumors, or subdural hematoma; Cognitive impairment due to vitamin B12 or folate deficiency; Neurosyphilis; Thyroid dysfunction; 2. Severe cases (cerebrovascular, heart, liver, kidney, gastrointestinal tract, endocrine metabolism, infectious diseases), digestive system cancer, gastrointestinal resection and inflammatory bowel disease; 3. Heavy use of drugs (antibiotics, intestinal disease drugs, laxatives, antidiarrheals) and health foods, supplements (lactic acid bacteria, bifidobacterium, lactic acid bacteria, low Glycan, dietary fiber); 4. Obvious abnormal blood pressure and blood tests; Severe anemia; Allergies to drugs and food; Heavy smokers and drinkers; Irregular lifestyle, such as diet type, sleep time; 5. Severe diabetes treated with anti-dementia drugs, psychoactive drugs, and insulin; 6. Participate in any other new drug research for AD; Participating in another new drug study; 7. Deemed unqualified by the principal researcher;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal flora;Brain-derived neurotrophic factor; Fecal flora genomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;Blood glucose;Blood fat; | — |
Countries
China
Contacts
Public ContactJie Li
Yixing People's Hospital
Outcome results
None listed