Dry eye
Conditions
Interventions
The control group:None
Sponsors
Hankou Aier Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of mild dry eye group: meeting the diagnostic criteria of dry eye; There were no obvious signs of ocular surface injury (corneal fluorescein staining points =5 corneal fluorescein staining points =30, BUT< 2s. Corneal fluorescein spots fuse into coarse spots, flakes or accompanied by filaments. Inclusion criteria of the non-dry eye group: according to the diagnostic criteria of dry eye in China's Expert Consensus on Clinical Diagnosis and Treatment of dry eye (2020 edition), the subjects had no signs and symptoms of dry eye.
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) Patients with eye surface drops of sodium fluorescein allergy; (2) Patients who have undergone eye surgery or trauma within the last 3 months; (3) Patients who received lacrimal embolization within 1 month; (4) active ocular surface infection or ocular surface infection within 1 month; (5) Patients with endophthalmitis or a history of endophthalmitis; (6) Patients with a history of viral keratitis infection; (7) Patients with thyroid-related eye diseases; (8) Patients with dry eye associated with sjogren's syndrome; (9) Patients who took doxycycline, glucocorticoids or other immunosuppressants orally within 1 month; (10) Patients with topical use of glucocorticoids and non-steroidal anti-inflammatory drugs within 2 weeks, and topical use of cyclosporine and immunosuppressants within 1 month; (11) Patients who have used diquafosol sodium eye drops; (12) Severe MGD patients (any of the following can be excluded) : 1) Eye discomfort affects work and life; 2) palpebral margin hypertrophy, obvious neovascularization, meibomian gland opening visible fat supposers; 3) No secretion was extruded from all glands; 4) Palpebral lipids are toothpaste-like; 5) Absence of meibomian gland > 2/3; 6) Corneal epithelium and superficial stroma were damaged.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The density of conjunctival goblet cells;LTA level; | — |
Secondary
| Measure | Time frame |
|---|---|
| the Chinese Dry Eye Questionnaire survey;CSF and TFBUT ;Schirmer I test; | — |
Countries
China
Contacts
Public ContactQingyan Zeng
Hankou Aier Eye Hospital
Outcome results
None listed