Esophageal cancer
Conditions
Interventions
Treatment Group:Pretreatment tooth cleaning + neoadjuvant immunochemotherapy
Sponsors
Department of Thoracic Surgery, West China Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Subjects must meet all of the following inclusion criteria before being enrolled in this study. (1) At the time of signing the informed consent, they were older than 18 years old (including 18 years old) and younger than 75 years old (including 75 years old), regardless of gender; (2) Locally advanced resectable esophageal cancer diagnosed clinically; (3) Plan to receive neoadjuvant chemoimmunotherapy and have the intention of surgical resection; (4) It was agreed to perform tooth cleaning intervention before neoadjuvant chemoimmunotherapy.
Exclusion criteria
Exclusion criteria: Subjects who meet any of the following criteria cannot be enrolled in this study. (1) Patients with esophageal cancer who had a previous history of chemoradiotherapy, immunotherapy or surgical treatment; (2) There are serious oral diseases, such as active periodontal disease, oral infection, etc., which are not suitable for dental cleaning intervention; (3) There are serious systemic diseases, such as cardiovascular disease, renal dysfunction, liver dysfunction, etc., which affect the reliability of the research results; (4) Other circumstances in which the investigator believes that the subject should not participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological complete response rate;R0 resection rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Composition of oral flora; | — |
Countries
China
Contacts
Public ContactYong Yuan
Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.
Outcome results
None listed