Obstructive sleep apnea hypopnea syndrome
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The age range is 25-60 years old, urban residents, junior high school education or above, control AHI = 80 times/h, BMI=35kg/m^2; 2. All patients were the first to be diagnosed, and no OSA-related surgery and ventilator therapy were performed; 3. No serious cardiovascular and cerebrovascular diseases, malignant tumors and other organ insufficiency diseases; 4. There are no contraindications to magnetic resonance and EEG examination.
Exclusion criteria
Exclusion criteria: 1. Patients with neurological and psychiatric diseases such as AD and schizophrenia, as well as patients who have taken drugs affecting the nervous and psychiatric system within 3 months; 2. Exclude other sleep disorders such as central apnea, sleep movement disorders, narcolepsy, etc.; 3. Patients using psychotropic medications; 4. Patients with pre-existing cognitive or neurological deficits; 5. Severe cardiovascular and cerebrovascular diseases and other serious diseases of organs (heart, kidney, liver, lung, central nervous system diseases, etc.) and malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Polysomnography data ;Questionnaire results;Cognitive assessment;Changes of MRI;Changes of EEG; | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolomics ;Proteomics ;Inflammatory markers;PALM model metrics;Genomics; | — |
Countries
China
Contacts
Public ContactRui Chen
The Second Affiliated Hospital of Soochow University
Outcome results
None listed