Esophageal Cancer
Conditions
Interventions
Treatment Group:Tooth Cleaning
Sponsors
West china hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Participants must meet all of the following inclusion criteria in order to be included in this study. (1) When signing the informed consent form, the age should be between 18 years old (inclusive) and 75 years old (inclusive); (2) Clinically diagnosed locally advanced resectable esophageal cancer; (3) Plan to receive neoadjuvant chemoradiotherapy and have the intention of surgical resection; (4) Agree to undergo dental cleaning intervention before neoadjuvant chemoradiotherapy.
Exclusion criteria
Exclusion criteria: If a subject meets any of the following criteria, they cannot be enrolled in this study. (1) Esophageal cancer patients with a history of radiotherapy, chemotherapy, or surgical treatment; (2) There are serious oral diseases, such as active periodontal disease, oral infections, etc., which are not suitable for dental cleaning intervention; (3) There are serious systemic diseases such as cardiovascular disease, renal dysfunction, liver dysfunction, etc., which affect the reliability of research results; (4) The researchers believe that participants should not participate in other situations of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pathologic complete response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune indicators, including white blood cell count, C-reactive protein (CRP), and cytokine levels (such as IL-6, TNF - a, etc.); | — |
Countries
China
Contacts
Public ContactYong Yuan
Department of thoracic surgery, West china hospital, Sichuan University
Outcome results
None listed