Hypertriglyceridemic acute pancreatitis
Conditions
Interventions
Experimental group(HTG-AP):None
Control group(Other causes of AP):None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.HTG-AP inclusion criteria Patients were eligible for inclusion in this prospective cohort study when they met all of the following criteria: a) were aged 18-80 years; b) Meet the diagnostic criteria for acute pancreatitis 1) acute, sudden, persistent, intense upper abdominal pain radiating to the back; 2)Serum amylase and/or lipase levels >= 3 times the upper limit of the reference range; 3)Enhanced CT or magnetic resonance imaging (MRI) showed typical AP imaging changes (pancreatic edema or peripancreatic effusion). Meeting 2 of the above 3 criteria can be diagnosed as AP; c) Combined with HTG, serum TG level > 1000 mg/dl (11.30mmol/L), or serum TG level between 500 to 1000 mg/dl (5.65 to 11.30mmol/L) but chylous; d) excluding other AP causes, such as cholelithiasis, alcohol, drugs, etc.; e) Good compliance, patients or family members are able to understand the study protocol and are willing to participate in the study and maintain their current lifestyle during the study, and provide written informed consent. 2.AP Inclusion Criteria for other Etiologies Patients could be included in this prospective cohort study if they met all of the following criteria: a) aged between 18 and 80 years; b) meet the diagnostic criteria for acute pancreatitis 1) acute, sudden, persistent, severe upper abdominal pain that radiates to the back; 2) serum amylase and/or lipase levels >= 3 times the upper limit of the reference range; 3) CT or MRI showed typical imaging changes of AP (pancreatic edema or peripancreatic effusion). AP can be diagnosed if two of the above three criteria are met.
Exclusion criteria
Exclusion criteria: 1.Patients could not be selected for clinical study if they had any of the following conditions: a) patients with chronic pancreatitis or pancreatic cancer b) suffering from serious organic diseases, such as malignant tumors, acute myocardial infarction, massive cerebral infarction, etc. c) use of any medication affecting serum TG levels 4 weeks before enrollment d) pregnant or lactating women, or those planning to become pregnant within 18 months of randomization e) No informed consent was signed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death; | — |
Secondary
| Measure | Time frame |
|---|---|
| Organ failure; | — |
Countries
China
Contacts
Public ContactWen Li
Peking Union Medical College Hospital
Outcome results
None listed