Primary focal dystonia
Conditions
Interventions
Experimental group - Blepharospasm:10 days of bilateral cerebellar cTBS therapy
Control group - Blepharospasm:10 days of bilateral cerebellar cTBS sham stimulation therapy
Experimental group -Cervical dystonia:10 days of bilateral cerebellar cTBS therapy
Control group - Cervical dystonia:10 days of bilateral cerebellar cTBS sham stimulation therapy
Experimental group - oromandibular dystonia:10 days of bilateral cerebellar cTBS therapy
Control group - oromandibular dystonia:10 days of bilateral cerebellar cTBS sham stimulation therapy
Sponsors
The First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with a clear diagnosis of primary blepharospasm, oromandibular dystonia, and cervical dystonia who have not been treated with botulinum toxin injections or who have had more than 4 months between botulinum toxin injections were selected; (2) Patients who had undergone various types of routine neurological examinations such as cranial MRI after the onset of the disease to exclude secondary dystonia caused by trauma, vascularity, and other neurological diseases; (3) The age range is 18-80 years old and gender is not limited; (4) All subjects and their families gave their informed consent to the examinations performed and signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with organic brain lesions; (2) Patients w ith poor compliance; (3) Patients with intracranial metallic foreign bodies such as cochlear implants, built-in pulse generators, DBS, etc. or pacemakers; (4) Patients with increased intracranial pressure, intracranial infection, large cerebral infarction, cerebral haemorrhage, intracranial tumour, epilepsy; (5) Women with the possibility of pregnancy or breastfeeding; (6) Subjects deemed by the investigator to be unsuitable for participation in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor symptom scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Non-motor symptom scale score; | — |
Countries
China
Contacts
Public ContactMing Shi
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed