postoperative quality of recovery
Conditions
Interventions
Esketamine group (K group):Group K patients were induced with 0.2 mg/kg cisatracurium, 1.5-3.0 mg/kg propofol, 0.3 µ g/kg sufentanil, and 0.2 mg/kg ketamine for anesthesia. Immediately after anesthesi
Composition of PCIA pump for patients in Group K: Ketorolac tromethamine injection 1.5 mg/kg, sufentanil 2 µ g/kg, and ketamine 0.1mg/kg, supplemented with physiological saline to 100ml
Control group(C group):Group C patients were induced to anesthesia with 0.2mg/kg cisatracurium, 1.5-3.0mg/kg propofol, 0.3 µ g/kg sufentanil, and 0.2mg/kg saline solution
Group C received immediate infusion of physiological saline at a dose of 0.1mg/kg/h during anesthesia induction
The PCIA pump for Group C patients consisted of 1.5 mg/kg ketorolac tromethamine injection and 2 µ g/kg sufentanil, supplemented with physiological saline to 100 mL.
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age over 18 years old; (2) ASA grades I-III; (3) Body mass index (BMI) 18-30 kg/m^2; (4) Patients undergoing elective laparoscopic radical gastrectomy for the first time.
Exclusion criteria
Exclusion criteria: (1) Refusal to participate in research; (2) Patients with severe heart failure (preoperative LVEF<50% or NYHA grade IV) or severe heart valve disease, severe liver dysfunction (Child Pugh grade C), severe renal dysfunction (preoperative dialysis); (3) Patients with infectious diseases, blood system diseases or autoimmune diseases; (4) Contraindications for ketamine (history of ketamine allergy, elevated intraocular pressure or intracranial pressure, etc.); (5) Patients who have recently received chemotherapy, radiotherapy, or endocrine therapy; (6) History of chronic pain or opioid use; (7) Patients with a family history of malignant hyperthermia or a high risk of malignant hyperthermia (such as strabismus, scoliosis, etc.); (8) Patients who are converted to open surgery, lost to follow-up, have a large amount of subcutaneous emphysema during surgery or postoperative hypercapnia that cannot be corrected in the short term, and have severe postoperative complications that affect the quality of postoperative recovery; (9) Refusal to participate in the study or any other circumstances that prevent the patient from cooperating with the study, such as language comprehension disorders, postoperative complications, etc.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Number of T cell subsets and CD4+/CD8+ratio;Inflammatory indicators: levels of peripheral blood inflammatory cytokines (CRP, IL-6, SAA, procalcitonin) before surgery, on postoperative day 1, and on postoperative day 3;Postoperative pain score; | — |
Primary
| Measure | Time frame |
|---|---|
| quality of recovery scores (QoR-15); | — |
Countries
China
Contacts
Public ContactJin Yanwu
The Second Hospital of Shandong University
Outcome results
None listed