Patients requiring sedation for elective surgery
Conditions
Interventions
Male dexmedetomidine group (MD group):The initial dose of intravenous dexmedetomidine infusion is 1.00 µg/kg, with a dose gradient of 0.05 µg/kg. Effective sedation is defined as a score of less than
conversely, if the score is equal to or greater than 3, the dose will be increased by 0.05 µg/kg. This process continues in the same manner until seven "ineffective sedation - effective sedation" cros
Female dexmedetomidine group (FD group):The initial dose of intravenous dexmedetomidine infusion is 1.00 µg/kg, with a dose gradient of 0.05 µg/kg. Effective sedation is defined as a score of less tha
Sponsors
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~60 years old; 2.BMI 18~30kg/m^2; 3. ASA Classification Class I or II
Exclusion criteria
Exclusion criteria: 1. Sinus bradycardia; 2. Patients with uncontrolled or difficult-to-control hypertension; 3. History of heart, lung, liver, and kidney diseases; 4. History of psychiatric and neurological diseases; 5. Coagulation dysfunction; 6. History of drug or alcohol abuse; 7. Pregnancy; 8. Those who are allergic to dexmedetomidine; 9. Patients who have recently taken antipsychotic drugs; 10. Persons with hearing and/or intellectual disabilities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The loading dose of dexmedetomidine;Median effective dose(ED50); | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Observer's Assessment of Alertness/Sedation Scale score;Bispectral index (BIS); | — |
Countries
China
Contacts
Public ContactLi Juan
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Outcome results
None listed