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Comparison of perioperative analgesic and sedative regimens in cardiac vascular surgery - Propofol versus esketamine

Comparison of perioperative analgesic and sedative regimens in cardiac vascular surgery - Propofol versus esketamine

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097877
Enrollment
Unknown
Registered
2025-02-26
Start date
2025-03-15
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac vascular surgery

Interventions

Experimental group:Esketamine + Butorphanol iv is pumped in
Control group:Pump in propofol + butorphanol iv

Sponsors

Department of Cardiac Vascular Surgery, West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients requiring analgesia and sedation during perioperative period of cardiac macrovascular Surgery in West China Hospital.

Exclusion criteria

Exclusion criteria: Exclusion criteria: (1) Hypertension SBP >= 180mmHg or intravenous antihypertensive drugs being used. (2) Tachyarrhythmia. (3) Ventricular arrhythmia. (4) Ischemic cardiomyopathy. (5) Severe aortic stenosis without surgical removal. (6) Increased intracranial pressure. (7) Untreated hyperthyroidism (8) History of serious mental disorders. (9) Glaucoma or penetrating eye trauma. (10) aminophylline or theophylline sustained release tablets are being used.

Design outcomes

Primary

MeasureTime frame
Mechanical ventilation time;—

Secondary

MeasureTime frame
Fast track failure rate;Non-invasive ventilation time;ICU time;tracheotomy;Organ failure;—

Countries

China

Contacts

Public ContactHui Kang

West China Hospital of Sichuan University

kkzaihuaxi@foxmail.com+86 138 8190 7302

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026