Coronary heart disease
Conditions
Interventions
Conventional treatment group:Western medicine basic treatment for secondary prevention of coronary heart disease
Test group:Take Guanxinning tablets orally
Sponsors
Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in clinical trials, sign informed consent forms, and follow the research process; 2. The age range is between 18 and 75 years old, including both genders; 3. Diagnosed as a patient with coronary heart disease.
Exclusion criteria
Exclusion criteria: 1. Occurred within 3 months: acute coronary syndrome, stroke, transient ischemic attack; cardiac or other macrovascular surgery; Percutaneous coronary intervention (PCI) or or coronary artery bypass grafting and other cardiac procedures; 2. Major surgery within 6 months prior to randomization; 3. Patients with active ulcers and abnormal coagulation function (hemoglobin less than 100g/L, platelet count less than 100×10^9/L or leukocyte =180mmHg and/or diastolic blood pressure >=110mmHg at two independent examinations prior to randomization; 8. Positive urine pregnancy test or lactating women; 9. Patients with allergies: such as patients who are known to be allergic to the study drug (including its components); 10. Those who are considered unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16S sequencing of gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine testing;TCM syndrome;C-reactive protein;Low-density lipoprotein cholesterol, LDL-C;High-density lipoprotein cholesterol, HDL-C;Cholesterol;Triglyceride;Homocysteine;Glutamic-pyruvic transaminase;Glutamic oxaloacetic transaminase;Urea nitrogen;Apoli popro tein A1,ApoA1;Apoli popro tein B,ApoB;a - Lipoprotein(a), Lp(a);Free Fatty Acids, FFA;Thromboxane,TXB2 ;6-keto-PGF1a;NO;Superoxide Dismutase, SOD;Malondialdehyde, MDA;Soluble CD40 Ligand, sCD40L;Matrix Metalloproteinase-9, MMP - 9; Alkaline Phosphatase, ALP;Gamma-glutamyltransferase, GGT;Total Serum Bilirubin, TBIL;Direct Bilirubin, DBil;Creatinine;IL-6;Activated Partial Thromboplastin Time, APTT;Prothrombin Time, PT;International Normalized Ratio, INR;Thrombin Time, TT;Fibrinogen, FIB;Routine urine test;Stool routine examination;Human Chorionic Gonadotropin, HCG;Electrocardiogram;Creatine kinase,CM;sCD40L;MMP-9;IL-6;Cardiovascular event rate;Waist circumference;Waist to hip ratio;BMI;Ankle brachial index; | — |
Countries
China
Contacts
Public ContactYu Huang
Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital
Outcome results
None listed