Schizophrenia
Conditions
Interventions
Study group 2:iTBS given at the left DLPFC stimulation site
Study group 1:iTBS was administered with the left cerebellar vermis as the target of stimulation.
Normal control group:Recruitment of 150 mentally and physically healthy normal individuals aged 18-40 years with no mental illness in their family. And their cranial magnetic resonance was collected
Sponsors
Shandong Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Meet DSM-5 diagnostic criteria for schizophrenia; 2. Age 18-40 years old, male or female, right-handed; 3. At present, negative symptoms are the main symptoms, and the factor score of the negative symptom scale of PANSS is >=20 points, and at least one of the negative symptoms of the PANSS is >=4 points; 4. Stable psychiatric symptoms, no obvious positive symptoms, PANSS positive symptom scale < 20 points, and each individual score needs to be <4 points; 5. Antipsychotic medication treatment was stable for at least 4 weeks prior to enrollment, and the medication regimen remained unchanged throughout the study. Normal control group: age 18-40 years; No family members with mental illness.
Exclusion criteria
Exclusion criteria: 1. Have severe cerebral organic diseases, such as epilepsy; 2. Accompanied by serious physical diseases, such as cardiovascular diseases, liver and kidney diseases, etc.; 3. History of substance abuse and psychoactive substance use; 4. Those who are mentally retarded and mentally retarded; 5. Those with contraindications to TMS treatment; 6. Pregnant or lactating women; 7. Received transcranial magnetic stimulation therapy or MECT therapy in the past six months; 8. Those with contraindications to magnetic resonance scanning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale, PANSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Repeatable Battery for the assessment of neuropsyc-hological status,RBANS;Hamilton Anxiety Scale,HAMA;Hamilton Depression Scale,HAMD; | — |
Countries
China
Contacts
Public ContactShan Xiaoxiao
Shandong Mental Health Center
Outcome results
None listed