Amnestic mild cognitive impairment
Conditions
Interventions
Control group:rTMS single-target stimulation was performed on the subjects. The NS3000-A magnetic field stimulator and an 8-shaped coil were used. The coil's maximum surface magnetic field strength wa
Acu + rTMS group:Acupuncture was performed at the "Baihui" and "Sishencong" points, with standard disinfection. Both Baihui and Sishencong were needled from anterior to posterior at an angle of approx
Acu + Sham rTMS group:Acupuncture was performed at the "Baihui" and "Sishencong" points using Hua Tuo brand single-use 1-inch acupuncture needles, with specifications of 0.25 × 25mm. Standard disinfec
Sponsors
Yueyang Integrated Medicine Hospital of Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Non-aMCI Inclusion Criteria: 1. Age > = 18 years old and = 18 years old and < = 80 years old, gender is not limited, right-handed; 3. Patients with aMCI complained of memory loss and had objective evidence (the long delayed recall score of the auditory word learning test was at least 1.0 or 1.5 standard deviations lower than the mean of the age-matched population); 4. Primary school degree or above; 5. Those who understand, agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Non-aMCI Exclusion Criteria: 1. Combined with tumors, serious heart, liver, kidney, blood system diseases or infectious diseases; 2. Neurological diseases such as cerebrovascular disease, Parkinson's syndrome, and dementia caused by various reasons in the past; 3. Severe audio-visual impairment, severe limb injury and other reasons that make it impossible to complete the neurobehavioral assessment; 4. Pre-existing mental illnesses such as anxiety, depression, and schizophrenia; 5. Magnetic resonance contraindications (such as: pacemaker, cardiac stent, artificial heart valve, fixed plate after fracture surgery, etc.). aMCI Exclusion Criteria: 1. Combined with tumors, serious heart, liver, kidney, blood system diseases or infectious diseases; 2. Neurological diseases such as cerebrovascular disease, Parkinson's syndrome, and dementia caused by various reasons in the past; 3. Mental illness such as anxiety, depression, and schizophrenia in the past; 4. Presence of severe audio-visual impairment that prevents the completion of the full set of neuropsychological scale assessments; 5. There are contraindications to transcranial magnetism, magnetic resonance or EEG (such as: pacemaker, cochlear implant, pulse generator, intracranial metal, scalp infection or trauma, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The fifth part of the Auditory Verbal Learning Test;Neuroelectrophysiological indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioral indicators;Imaging indicators; | — |
Countries
China
Contacts
Public ContactJie Ma
Yueyang Integrated Medicine Hospital of Shanghai University of Traditional Chinese Medicine
Outcome results
None listed