Pain after hip replacement surgery
Conditions
Interventions
Control group:Flurbiprofen axidate group was given 100mg flurbiprofen axidate 15min before operation
Test group 1:Ulinastatin 10IU group was given 10IU ulinastatin 15min before operation
Test group 2:Ulinastatin 20IU group was given 20IU of ulinastatin 15min before operation
Sponsors
Tianjin Jizhou District People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients >=60 years of age who need total/semi-hip replacement 2. Awake and able to understand the VAS score 3.ASA is graded from ? to ? 4. Patients who signed a written informed consent for the study
Exclusion criteria
Exclusion criteria: 1. Patients with neuropathic pain (such as tumor pressing on nerve stem, plexus, spinal cord) who are using or are considered by their doctor to need antipanic or antidepressants; Analgesics other than the study drug are being used or are considered necessary by a doctor; 2. There are unstable diseases such as digestive tract ulcers; Or patients with dysfunction of vital organs; 3. Patients with a known allergy to opioids; 4. Patients who are likely to change their concomitant medications (other than those treating adverse opioid reactions) during the study period; 5. According to the judgment of the investigator, patients who are not suitable to participate in this study for any reason other than the inclusion criteria and exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption;The occurrence of postoperative adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score (VAS 0-10);Pain and inflammatory factors: bradykinin, IL-6 and IL-8;Liver and kidney function: creatinine, transaminase; | — |
Countries
China
Contacts
Public ContactYan Li
Tianjin Jizhou District People's Hospital
Outcome results
None listed