Nasopharyngeal carcinoma
Conditions
Interventions
Control group:IMRT+IMCT
Study Group:IMPT+IMCT
Sponsors
Shanghai Proton and Heavy Ion Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Willing to sign the written informed consent; Informed consent must be signed before the enrollment in the trial. 2.Pathologically confirmed Nasopharyngeal carcinoma(WHO II/III type). 3.Diagnosed with stage with III-Iva (exclude T3N0) (AJCC 8th stage); 4.Age > 18 and = 1500/uL b. Platelets >= 100,000/uL c. Hemoglobin >= 9 g/dL d. Serum creatinine = 60 mL/min e. Total bilirubin <= 1.5×ULN f. AST vs. ALT <= 2.5×ULN; 7.Willing to accept adequate contraception for women with childbearing potential.
Exclusion criteria
Exclusion criteria: 1.Presence of distant metastasis. 2.Received radiotherapy for head and neck before. 3.Received surgery(except for biopsy) for primary lesion or cervical lymph node. 4.Previous history of malignant tumor (within 5 years) or simultaneous existence of multiple primary tumors. 5.Presence of diseases (such as Sjögren syndrome) that may interfere evaluation of endpoint. 6.Accompanied with severe major organ dysfunction. 7.Presence of mental disease that may influence the understanding of informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Countries
China
Contacts
Public ContactJiyi Hu
Shanghai Proton and Heavy Ion Center
Outcome results
None listed