Urinary calculus
Conditions
Interventions
Esketamine group:Intravenous injection 0.25mg/Kg esketamine
Normal saline group:Use the same dose of saline
Sponsors
The Second Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I - II 2. Age 18-80 years old 3. Patients undergoing percutaneous nephrolithotomy at selected time 4. BMI 18-30;
Exclusion criteria
Exclusion criteria: 1.Patients with surgical contraindications, such as coagulation dysfunction, infectious diseases, immune diseases, etc. 2.Patients with severe malignant tumors or cardiovascular and cerebrovascular diseases; 3.Hypertension is poorly controlled 4.Patients with mental or nervous system diseases; Pregnant or lactating women or subjects (including men) who plan to have a baby within 6 months; 5.Allergic to narcotic drugs; 6.Unwilling to participate in the experiment, clinical data lost;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Recovery Scale -40 score;Self-rating anxiety scale;Self-rating depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, MAP;Operation time;Respiratory recovery time (from withdrawal of anesthesia to recovery of spontaneous respiration);VAS pain score ;Postoperative adverse reactions (including nausea and vomiting, dreaminess, nightmares, dizziness and headache);Age;Extubation time (from withdrawal of anesthesia Time to extubation);Sex;ASA rating;BMI;Propofol dosage;Remifentanil dosage;Vasoactive drug use;Remedy the analgesic condition during PACU; | — |
Countries
China
Contacts
Public ContactZhang Yongfa
The Second Affiliated Hospital of Shantou University Medical College,Department of Anesthesiology
Outcome results
None listed