Postoperative Delirium
Conditions
Interventions
Group A:Dexmedetomidine 1 µg·kg-1
Group B:Dexamethasone 0.1mg·kg-1
Group C:Esketamine0.5mg·kg-1
Group D:normal saline
Sponsors
Tianjin Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 65-90 years old; 2. ASA classification I~III; 3. Meets the criteria for hip joint surgery under iliac fascia block; 4. No delirium before surgery; 5. No neuropathy or myopathy in the lower limbs; 6. No coagulation dysfunction; 7. No history of Alzheimer's disease, stroke, or mental illness; 8. Preoperative simple mental state examination score>18 points; 9. Meet the conditions for spinal anesthesia; 10. The patient or the patient's legal representative is able and willing to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. The patient refused to use dexamethasone, dexmedetomidine, and ketamine; 2. The patient has contraindications for the use of dexamethasone, dexmedetomidine, and escitalopram; 3. Suspected anesthesia poisoning reaction; 4. Accompanied by any serious illness, expected survival time<6 months; 5. Individuals who cannot express subjective discomfort symptoms; 6. Postoperative ICU patients; 7. Other situations that the researcher deems unsuitable for participation in this study; 8. Failed iliac fascia block or spinal canal operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insomnia incidence rate;VAS scores;RASS scores;Preoperative and postoperative C-reactive protein (CRP);Preoperative and postoperative IL-6; | — |
Countries
China
Contacts
Public ContactJin Xu
Department of Anesthesiology,Tianjin Hospital
Outcome results
None listed