Analgesia during mechanical ventilation after cardiac surgery
Conditions
Interventions
Propofol + hydromorphone group:None
Propofol + butorphanol group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, gender is not limited; 2.Undergoing cardiac surgery; 3.The postoperative mechanical ventilation time is expected to be greater than 12 hours; 4.Sedation and analgesia treatment is required, and the expected sedation and analgesia time is >=6 hours; 5. No history of nausea, vomiting, pruritus and drug allergy before operation; 6.No history of opioid use in the 2 weeks prior to joining the study.
Exclusion criteria
Exclusion criteria: 1.Hemodynamics are unstable, requiring epinephrine or norepinephrine > 0.1ug/kg/min or aortic balloon counterpulsation to maintain hemodynamics; 2.Preoperative cardiac function was poor, EF < 30%; Patients with severe liver and kidney dysfunction before operation; 3. Patients with chronic inflammatory diseases or chronic obstructive pulmonary disease; 4.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesic effect;Sedative effect;Heart rate, blood pressure, mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety indicators; | — |
Countries
China
Contacts
Public ContactXiang Yuping
West China Hospital of Sichuan University
Outcome results
None listed