Rectal cancer
Conditions
Interventions
Early Reversal Group (Before Adjuvant Therapy):Closure of the ileostomy before the initiation of adjuvant therapy, specifically 8–16 days after rectal surgery.
Late Reversal Group (After Adjuvant Therapy):Closure of the ileostomy within 15–60 days after the completion of adjuvant therapy.
Sponsors
People’s Hospital of Deyang City
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with rectal cancer who have undergone radical anterior rectal resection (R0 resection) and temporary ileostomy at the same time have no clinical manifestations of anastomotic leakage after surgery. Age & Physical Condition: 1. Age>=18 years old, with independent informed consent capacity; 2. Physical condition meets the indications for adjuvant therapy (ECOG score 0-1 points); 3. Indications for adjuvant therapy: according to postoperative pathological results and clinical evaluation, there are indications for adjuvant chemotherapy; 4. Willing to participate in this study and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Poor general condition: 1. ASA score > 3, indicating high risk of surgery or anesthesia; 2. ECOG score >=2 points, indicating poor physical functional status. Advanced or complex tumors: 1. UICC tumor stage is stage IV; 2. Anastomotic leakage or other serious complications after surgery. Other medical contraindications: 1. Presence of severe and uncontrollable systemic disease (such as heart failure, renal failure, or active infection); 2. Have other serious psychological or psychiatric disorders that affect treatment compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemotherapy Compliance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stoma-Related Complications;Surgical Complications;Chemotherapy Toxicity;Psychological Status;Quality of Life;Anorectal Function; | — |
Countries
China
Contacts
Public ContactZhang Mingran
People’s Hospital of Deyang City
Outcome results
None listed