ischemic cerebrovascular disease
Conditions
Interventions
Phenylephrine group:After general anesthesia is stable, phenylephrine is infused intravenously and blood pressure is maintained at the baseline level
when the carotid artery is clamped, the concentration or administration rate of phenylephrine is adjusted to maintain blood pressure 20% higher than the baseline level
the infusion is stopped when the carotid artery is open.Remaining operation was consistent with routine general anesthesia.
Norepinephrine group:After general anesthesia is stable, norepinephrine is infused intravenously and blood pressure is maintained at the baseline level
when the carotid artery is clamped, the concentration or administration rate of norepinephrine is adjusted to maintain blood pressure 20% higher than the baseline level
Sponsors
Qinghai University Affiliated Hospital (School of Clinical Medicine)
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age: 40-80 years; (2) Elective carotid endarterectomy; (3) Signed informed consent.
Exclusion criteria
Exclusion criteria: (1) ASA grade IV-VI; (2) renal failure; (3) severe arrhythmia; (4) myocardial infarction, heart failure; (5) no mental disorder and severe visual and auditory impairment; (6) able to complete the preoperative cognitive function test independently, and the preoperative MMSE (Mini-Mental State Examination) score is >=23 points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional cerebral oxygenation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Success rate of vasopressors in achieving target blood pressure;Wake-up quality;Postoperative delirium;Postoperative Mini-Mental State Examination (MMSE) score;Incidence of intraoperative and postoperative complications; | — |
Countries
China
Contacts
Public ContactLiu Haiyang/ Li Guiyu
Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University/ Anesthesia Department, Qinghai University Affiliated Hospital
Outcome results
None listed